《补充磷虾油对运动员成绩和免疫功能的影响》Mariasole Da Boit, Ina Mastalurova et al.PLOS ONE|DOI:10.1371/journal.pone.0139174 September25,2015|中冠生物科技(珲春)有限公司 

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《补充磷虾油对运动员成绩和免疫功能的影响》

Mariasole Da Boit, Ina Mastalurova et al.PLOS ONE|DOI:10.1371/journal.pone.0139174 September25,2015

摘要:
背景:

磷虾油含有丰富的长链n-3多不饱和脂肪酸(PUFAs)、二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),可以改变运动员训练后的免疫功能。本研究的目的是确定运动员补充磷虾油后对免疫功能和训练成绩的影响。
方法:
随机挑选19名男性运动员,18名女性运动员(平均年龄:25.8±5.3岁;平均值±方差),一组每天补充2克磷虾油(n = 18),一组补充安慰剂(n = 19),连续进行6周。在补充磷虾油或安慰剂前后分别进行最大增量运动试验和循环计时试验(完成设定运动量所需的时间)。在服用补充剂前后的休息时间和运动训练后的1-3小时间采集运动员的血样。测定血样中血浆IL-6和硫代巴比妥酸反应物质(TBARS)浓度,并测定血红细胞中的脂肪酸组成。测定自然杀伤细胞(NK)的杀伤活性与外周血单核细胞(PBMC) IL-2、IL-4、IL-10、IL-17活性和IFNγ的数量。
结果:
没有发现性别对任一组变量产生影响。与对照组相比,补充磷虾油组运动员在训练后3小时外周血单核细胞PBMC IL-2数量和自然杀伤细胞的杀伤活性显著增强(P < 0.05)。在训练期间,补充磷虾油组和补充安慰剂组的运动员在血浆IL-6、硫代巴比妥酸反应物质(TBARS)浓度、外周血单核细胞(PBMC) IL-4、IL-10、IL-17和IFNγ数量上没有显著性差异。
结论:
对于健康的年轻男女运动员,连续补充六周磷虾油可以在训练结束后3小时增加外周血单核细胞PBMC IL-2的数量和自然杀伤细胞的杀伤活性。磷虾油不会改善运动员的训练成绩。
 
Abstract
Background

Methods
Nineteen males and 18 females (age: 25.8 ± 5.3 years; mean ± S.D.) were randomly assigned to 2 g/day of krill oil (n = 18) or placebo (n = 19) supplementation for 6 weeks. Amaximal incremental exercise test and cycling time trial (time to complete set amount of work) were performed pre-supplementation with the time trial repeated post-supplementation. Blood samples collected pre- and post- supplementation at rest, and immediately, 1 and 3h post-exercise. Plasma IL-6 and thiobarbituric acid reactive substances (TBARS) concentrations and, erythrocyte fatty acid composition were measured. Natural killer (NK) cell cytotoxic activity and peripheral blood mononuclear cell (PBMC) IL-2, IL-4, IL-10, IL-17 and IFNγ production were also measured.

Results

No effects of gender were noted for any variable. PBMC IL-2 and NK cell cytotoxic activity were greater (P < 0.05) 3h post exercise in the krill oil compared to the control group. Plasma IL-6 and TBARS, PBMC IL-4, IL-10, IL-17 and IFNγ production, along with performance and physiological measures during exercise, were not different between groups.

Conclusion

Six weeks of krill oil supplementation can increase PBMC IL-2 production and NK cell cytotoxic activity 3h post-exercise in both healthy young males and females. Krill oil does not modify exercise performance.