Amanda Rundblad , Kirsten B. Holven et al.Journal of Nutritional Science (2018), vol. 7, e3, page 1 of 11
食用含n-3脂肪酸的鱼可以降低心血管病的风险。而磷虾油作为海洋n-3脂肪酸的替代物，对健康的影响却很少研究。因此，我们比较了在含有等量n-3脂肪酸的情况下，食用磷虾油补充剂和鱼，对不同心血管标记物的影响。在一项为期8周的随机平行研究中，36名18-70岁健康受试者，空腹血清的甘油三酯水平在1.3-4.0mmol / L之间，被随机分配，分别食用鱼、磷虾油或对照油。在食用鱼的组，受试者根据饮食习惯，分别食用脂肪含量少和含量多的鱼。在磷虾油组和对照组，每天服用8粒胶囊，含4克油。食用鱼的组和服用磷虾油的组，每周从鱼和磷虾油中获得的海洋n-3脂肪酸的含量分别是4103和 4654 mg。空腹血清的甘油三酯水平在各组之间没有显著性变化。极低密度脂蛋白亚类中的总脂（P = 0.007）、磷脂（P = 0.015）、胆固醇（P = 0.009）、胆固醇酯（P = 0.022）和非酯化胆固醇（P = 0.002）水平，在服用磷虾油补充剂后明显增高。服用磷虾组血糖明显下降（P = 0.024），食用鱼的组维生素D显著增加（P = 0.024）。与对照组相比，服用磷虾油组和食用鱼组血浆中的海洋n-3脂肪酸含量显著增加(所有 P≤0.0003)。总之，补充磷虾油和摄入鱼类会对健康产生有益的影响。而只有磷虾油可以降低空腹血糖，鱼类可提供健康有益的营养物质，包括维生素D。
Fish consumption and supplementation with n-3 fatty acids reduce CVD risk. Krill oil is an alternative source of marine n-3 fatty acids and few studies have investigated its health effects. Thus, we compared krill oil supplementation with the intake of fish with similar amounts of n-3 fatty acids on different cardiovascular risk markers. In an 8-week randomised parallel study, thirty-six healthy subjects aged 18–70 years with fasting serum TAG between 1·3 and 4·0 mmol/l were randomised to receive either fish, krill oil or control oil. In the fish group, subjects consumed lean and fatty fish, according to dietary guidelines. The krill and control group received eight capsules per d containing 4 g oil per d. The weekly intake of marine n-3 fatty acids from fish given in the fish group and from krill oil in the krill group were 4103 and 4654 mg, respectively. Fasting serum TAG did not change between the groups. The level of total lipids (P =0·007), phospholipids (P=0·015), cholesterol (P =0·009), cholesteryl esters (P =0·022) and non-esterified cholesterol (P=0·002) in the smallest VLDL subclass increased significantly in response to krill oil supplementation. Blood glucose decreased significantly (P=0·024) in the krill group and vitamin D increased significantly in the fish group (P =0·024). Furthermore, plasma levels of marine n-3 fatty acids increased significantly in the fish and krill groups compared with the control (all P≤0·0003). In conclusion, supplementation with krill oil and intake of fish result in health-beneficial effects. Although only krill oil reduced fasting glucose, fish provide health-beneficial nutrients, including vitamin D.